AFF1 Antibody (PACO21795)
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주문- SKU:
- PACO21795
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | AFF1 Antibody (PACO21795) |
Antibody SKU: | PACO21795 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:50-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from N-terminal of human AF4. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Gu Y., Cell 71:701-708(1992). |
Clonality: | Polyclonal |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using AF4 antibody. |
Synonyms: | AF4; AFF1; FEL protein; MLLT2; Proto-oncogene AF4 |
UniProt Protein Function: | AF-4: A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with MLL/HRX. The result is a rogue activator protein. Belongs to the AF4 family. |
UniProt Protein Details: | Protein type:Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 4q21 Cellular Component: transcription elongation factor complex Molecular Function:protein binding; transcription factor activity Biological Process: positive regulation of transcription, DNA-dependent |
NCBI Summary: | This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
UniProt Code: | P51825 |
NCBI GenInfo Identifier: | 1703194 |
NCBI Gene ID: | 4299 |
NCBI Accession: | P51825.1 |
UniProt Secondary Accession: | P51825,B4DTU1, E9PBM3, |
UniProt Related Accession: | P51825 |
Molecular Weight: | 1210 |
NCBI Full Name: | AF4/FMR2 family member 1 |
NCBI Synonym Full Names: | AF4/FMR2 family, member 1 |
NCBI Official Symbol: | AFF1 |
NCBI Official Synonym Symbols: | AF4; PBM1; MLLT2 |
NCBI Protein Information: | AF4/FMR2 family member 1; protein AF-4; proto-oncogene AF4; pre-B-cell monocytic leukemia partner 1; ALL1-fused gene from chromosome 4 protein; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2 |
UniProt Protein Name: | AF4/FMR2 family member 1 |
UniProt Synonym Protein Names: | ALL1-fused gene from chromosome 4 protein; Protein AF-4; Protein FEL; Proto-oncogene AF4 |
Protein Family: | AF4/FMR2 family |
UniProt Gene Name: | AFF1 |
UniProt Entry Name: | AFF1_HUMAN |