ADRA2C Antibody (PACO00416)
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주문- SKU:
- PACO00416
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ADRA2C Antibody |
Antibody SKU: | PACO00416 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the C-terminal region of human AR alpha2C. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | ADRA2C; ADRA2L2; ADRA2RL2; Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2CAR |
UniProt Protein Function: | ADRA2C: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR Chromosomal Location of Human Ortholog: 4p16 Cellular Component: cytoplasm; endosome; integral to plasma membrane; plasma membrane Molecular Function:alpha-2A adrenergic receptor binding; alpha2-adrenergic receptor activity; epinephrine binding; protein binding; protein heterodimerization activity; protein homodimerization activity Biological Process: activation of protein kinase B; cell-cell signaling; G-protein coupled receptor protein signaling pathway; positive regulation of neuron differentiation; regulation of insulin secretion |
NCBI Summary: | Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008] |
UniProt Code: | P18825 |
NCBI GenInfo Identifier: | 20141211 |
NCBI Gene ID: | 152 |
NCBI Accession: | P18825.2 |
UniProt Secondary Accession: | P18825,P35369, Q9HB49, |
UniProt Related Accession: | P18825 |
Molecular Weight: | 49,522 Da |
NCBI Full Name: | Alpha-2C adrenergic receptor |
NCBI Synonym Full Names: | adrenoceptor alpha 2C |
NCBI Official Symbol: | ADRA2C |
NCBI Official Synonym Symbols: | ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR |
NCBI Protein Information: | alpha-2C adrenergic receptor |
UniProt Protein Name: | Alpha-2C adrenergic receptor |
UniProt Synonym Protein Names: | Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2CAR |
Protein Family: | Alpha-2C adrenergic receptor |
UniProt Gene Name: | ADRA2C |
UniProt Entry Name: | ADA2C_HUMAN |