ADIPOR1 Antibody (PACO14008)
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주문- SKU:
- PACO14008
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ADIPOR1 Antibody (PACO14008) |
Antibody SKU: | PACO14008 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human ADIPOR1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14008(ADIPOR1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse thymus tissue, Primary antibody: PACO14008(ADIPOR1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO14008(ADIPOR1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid, catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid, oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. |
Synonyms: | Adiponectin receptor 1 |
UniProt Protein Function: | ADIPOR1: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. Belongs to the ADIPOR family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: membrane; plasma membrane; integral to membrane Molecular Function:adiponectin binding; identical protein binding; hormone binding; protein heterodimerization activity; receptor activity; protein kinase binding Biological Process: hormone-mediated signaling; adiponectin-mediated signaling pathway; positive regulation of JAK-STAT cascade; fatty acid oxidation; negative regulation of cell growth; positive regulation of insulin receptor signaling pathway; leptin-mediated signaling pathway |
NCBI Summary: | This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014] |
UniProt Code: | Q96A54 |
NCBI GenInfo Identifier: | 38372248 |
NCBI Gene ID: | 51094 |
NCBI Accession: | Q96A54.1 |
UniProt Secondary Accession: | Q96A54,Q53HS7, Q53YY6, Q9Y360, B3KMB0, |
UniProt Related Accession: | Q96A54 |
Molecular Weight: | 375 |
NCBI Full Name: | Adiponectin receptor protein 1 |
NCBI Synonym Full Names: | adiponectin receptor 1 |
NCBI Official Symbol: | ADIPOR1 |
NCBI Official Synonym Symbols: | CGI45; PAQR1; ACDCR1; CGI-45; TESBP1A |
NCBI Protein Information: | adiponectin receptor protein 1; progestin and adipoQ receptor family member I |
UniProt Protein Name: | Adiponectin receptor protein 1 |
UniProt Synonym Protein Names: | Progestin and adipoQ receptor family member I |
Protein Family: | Adiponectin receptor protein |
UniProt Gene Name: | ADIPOR1 |
UniProt Entry Name: | ADR1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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