ADAMTSL4 Antibody (PACO45279)
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주문- SKU:
- PACO45279
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ADAMTSL4 Antibody (PACO45279) |
Antibody SKU: | PACO45279 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human ADAMTS-like protein 4 protein (795-1074AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO45279 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO45279 at dilution of 1:100. |
Background: | Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. |
Synonyms: | ADAMTS-like protein 4 (ADAMTSL-4) (Thrombospondin repeat-containing protein 1), ADAMTSL4, TSRC1 |
UniProt Protein Function: | TSRC1: Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. Defects in ADAMTSL4 are a cause of autosomal recessive isolated ectopia lentis (ARI-EL). ARI-EL is a rare condition characterized by partial or complete displacement of the lens from its space resulting from defective zonule formation. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: endoplasmic reticulum lumen Molecular Function:protein binding; protease binding; metalloendopeptidase activity Biological Process: protein amino acid O-linked glycosylation; extracellular matrix organization and biogenesis; cellular protein metabolic process; apoptosis; positive regulation of apoptosis; proteolysis; post-translational protein modification Disease: Ectopia Lentis 2, Isolated, Autosomal Recessive; Ectopia Lentis Et Pupillae |
NCBI Summary: | This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Sep 2014] |
UniProt Code: | Q6UY14 |
NCBI GenInfo Identifier: | 118573317 |
NCBI Gene ID: | 54507 |
NCBI Accession: | Q6UY14.2 |
UniProt Secondary Accession: | Q6UY14,Q5T5F7, Q6IPM6, Q8N643, Q9HBS6, B2RTT0, F8WAD0 |
UniProt Related Accession: | Q6UY14 |
Molecular Weight: | 1074 |
NCBI Full Name: | ADAMTS-like protein 4 |
NCBI Synonym Full Names: | ADAMTS-like 4 |
NCBI Official Symbol: | ADAMTSL4 |
NCBI Official Synonym Symbols: | TSRC1; ECTOL2; ADAMTSL-4 |
NCBI Protein Information: | ADAMTS-like protein 4; thrombospondin repeat-containing protein 1 |
UniProt Protein Name: | ADAMTS-like protein 4 |
UniProt Synonym Protein Names: | Thrombospondin repeat-containing protein 1 |
Protein Family: | ADAMTS-like protein |
UniProt Gene Name: | ADAMTSL4 |
UniProt Entry Name: | ATL4_HUMAN |