Anti-ADAMTS1 항체의 (PACO20984)

Antibody Name:	ADAMTS1 Antibody (PACO20984)
Antibody SKU:	PACO20984
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human ADAMTS1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20984(ADAMTS1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20984(ADAMTS1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.

Synonyms:

ADAM metallopeptidase with thrombospondin type 1 motif, 1

UniProt Protein Function:	ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
UniProt Protein Details:	Protein type:Protease; Secreted, signal peptide; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted Chromosomal Location of Human Ortholog: 21q21.2 Cellular Component: basement membrane; cytoplasm; cytoplasmic vesicle Molecular Function:heparin binding; metalloendopeptidase activity; metallopeptidase activity; zinc ion binding Biological Process: integrin-mediated signaling pathway; kidney development; negative regulation of cell proliferation; ovulation from ovarian follicle; proteolysis
NCBI Summary:	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9UHI8
NCBI GenInfo Identifier:	124053460
NCBI Gene ID:	9510
NCBI Accession:	Q9UHI8.4
UniProt Secondary Accession:	Q9UHI8,Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80, D3DSD5,
UniProt Related Accession:	Q9UHI8
Molecular Weight:	105,358 Da
NCBI Full Name:	A disintegrin and metalloproteinase with thrombospondin motifs 1
NCBI Synonym Full Names:	ADAM metallopeptidase with thrombospondin type 1 motif 1
NCBI Official Symbol:	ADAMTS1
NCBI Official Synonym Symbols:	C3-C5; METH1
NCBI Protein Information:	A disintegrin and metalloproteinase with thrombospondin motifs 1
UniProt Protein Name:	A disintegrin and metalloproteinase with thrombospondin motifs 1
UniProt Synonym Protein Names:	METH-1
Protein Family:	A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name:	ADAMTS1
UniProt Entry Name:	ATS1_HUMAN

Antibodies	ELISA Kits
Anti-ADAMTS1 Antibody (CAB15356)	Human ADAMTS1 ELISA Kit
ADAMTS1 Antibody (PACO06233)	Human A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)