ADA Antibody (PACO24751)
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주문- SKU:
- PACO24751
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ADA Antibody (PACO24751) |
Antibody SKU: | PACO24751 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Adenosine deaminase protein (157-343AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot All lanes: ADA antibody at 2µg/ml + Jurkat whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 41 kDa Observed band size: 41 kDa . |
![]() | Immunohistochemistry of paraffin-embedded human cervical cancer using PACO24751 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO24751 at dilution of 1:100. |
Background: | Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. |
Synonyms: | Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase), ADA, ADA1 |
UniProt Protein Function: | ADA: a enzyme that converts adenosine + H2O into inosine + NH3. Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues. Genetic ADA deficiencies are a cause of autosomal recessive severe combined immuno-deficiency (SCID). Hereditary hemolytic anemia is caused by expression levels in erythrocytes 50-70 times greater than the norm. |
UniProt Protein Details: | Protein type:Hydrolase; Nucleotide Metabolism - purine; EC 3.5.4.4 Chromosomal Location of Human Ortholog: 20q13.12 Cellular Component: cell surface; cytoplasm; cytosol; external side of plasma membrane; lysosome; membrane; plasma membrane Molecular Function:adenosine deaminase activity; protein binding; zinc ion binding Biological Process: adenosine catabolic process; hypoxanthine salvage; inosine biosynthetic process; negative regulation of adenosine receptor signaling pathway; purine nucleotide salvage; purine salvage; regulation of cell-cell adhesion mediated by integrin; response to hypoxia; T cell activation Disease: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-negative, Nk Cell-negative, Due To Adenosine Deaminase Deficiency |
NCBI Summary: | This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008] |
UniProt Code: | P00813 |
NCBI GenInfo Identifier: | 113339 |
NCBI Gene ID: | 100 |
NCBI Accession: | P00813.3 |
UniProt Secondary Accession: | P00813,Q53F92, Q6LA59, |
UniProt Related Accession: | P00813 |
Molecular Weight: | 40,764 Da |
NCBI Full Name: | Adenosine deaminase |
NCBI Synonym Full Names: | adenosine deaminase |
NCBI Official Symbol: | ADA |
NCBI Protein Information: | adenosine deaminase |
UniProt Protein Name: | Adenosine deaminase |
UniProt Synonym Protein Names: | Adenosine aminohydrolase |
Protein Family: | ADAM |
UniProt Gene Name: | ADA |
UniProt Entry Name: | ADA_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |