ACVR1C Antibody (PACO43776)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO43776
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ACVR1C Antibody (PACO43776) |
Antibody SKU: | PACO43776 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Activin receptor type-1C protein (22-113AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: ACVR1C antibody at 4µg/ml. Lane 1: Mouse brain tissue. Lane 2: HepG2 whole cell lysate. Lane 3: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 55, 38, 47, 50 kDa. Observed band size: 55 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO43776 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human colon cancer using PACO43776 at dilution of 1:100. |
Background: | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. |
Synonyms: | Activin receptor type-1C (EC 2.7.11.30) (Activin receptor type IC) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7), ACVR1C, ALK7 |
UniProt Protein Function: | ALK7: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; Membrane protein, integral; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily Chromosomal Location of Human Ortholog: 2q24.1 Cellular Component: plasma membrane; activin receptor complex Molecular Function:transforming growth factor beta receptor activity; activin receptor activity, type I; metal ion binding; growth factor binding; ATP binding; receptor signaling protein serine/threonine kinase activity Biological Process: response to dietary excess; sequestering of lipid; apoptotic nuclear changes; response to glucose stimulus; positive regulation of caspase activity; cell differentiation; protein amino acid phosphorylation; negative regulation of insulin secretion; response to insulin stimulus |
NCBI Summary: | ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q8NER5 |
NCBI GenInfo Identifier: | 74762565 |
NCBI Gene ID: | 130399 |
NCBI Accession: | Q8NER5.1 |
UniProt Secondary Accession: | Q8NER5,Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2, |
UniProt Related Accession: | Q8NER5 |
Molecular Weight: | Calculated MW: 37kDa/46kDa/49kDa/54kDaObserved MW: 60kDa |
NCBI Full Name: | Activin receptor type-1C |
NCBI Synonym Full Names: | activin A receptor, type IC |
NCBI Official Symbol: | ACVR1C |
NCBI Official Synonym Symbols: | ALK7; ACVRLK7 |
NCBI Protein Information: | activin receptor type-1C; ALK-7; ACVR1C; ACTR-IC; activin receptor type IC; activin receptor-like kinase 7 |
UniProt Protein Name: | Activin receptor type-1C |
UniProt Synonym Protein Names: | Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7 |
Protein Family: | Activin receptor |
UniProt Gene Name: | ACVR1C |
UniProt Entry Name: | ACV1C_HUMAN |