ACTN3 Antibody (PACO15283)
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주문- SKU:
- PACO15283
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ACTN3 Antibody (PACO15283) |
Antibody SKU: | PACO15283 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human ACTN3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, NIH/3T3 cells, Primary antibody: PACO15283(ACTN3 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
Background: | This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants. The reference genome contains the non-coding allele. The non-functional allele of this gene is associated with elite athlete status. |
Synonyms: | Actinin, α 3 |
UniProt Protein Function: | ACTN3: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Belongs to the alpha-actinin family. |
UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: actin filament; cytosol; focal adhesion; intracellular; pseudopodium Molecular Function:integrin binding; protein binding; protein homodimerization activity; structural constituent of muscle Biological Process: focal adhesion formation; muscle filament sliding; negative regulation of glycolysis; positive regulation of skeletal muscle growth; regulation of the force of skeletal muscle contraction; response to denervation involved in regulation of muscle adaptation; skeletal muscle atrophy; transition between fast and slow fiber |
NCBI Summary: | This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the coding allele. The non-functional allele of this gene is associated with elite athlete status. [provided by RefSeq, Feb 2014] |
UniProt Code: | Q08043 |
NCBI GenInfo Identifier: | 215273967 |
NCBI Gene ID: | 89 |
NCBI Accession: | Q08043.2 |
UniProt Secondary Accession: | Q08043,Q4KKV2, A6NP77, |
UniProt Related Accession: | Q08043 |
Molecular Weight: | 103kDa |
NCBI Full Name: | Alpha-actinin-3 |
NCBI Synonym Full Names: | actinin alpha 3 (gene/pseudogene) |
NCBI Official Symbol: | ACTN3 |
NCBI Protein Information: | alpha-actinin-3 |
UniProt Protein Name: | Alpha-actinin-3 |
UniProt Synonym Protein Names: | Alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein |
Protein Family: | Alpha-actinin |
UniProt Gene Name: | ACTN3 |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |